Aging-US published “Impact of adiposity on muscle function and clinical events among elders with dynapenia, presarcopenia and sarcopenia: a community-based cross-sectional study” which reported that low muscle function determined unfavorable clinical outcome than low muscle mass; nevertheless, comparison of detrimental parameters among dynapenia, presarcopenia and sarcopenia was sparse.
The authors hypothesized that adiposity is implicated in low muscle function related adverse events.
Associations of different obesity parameters, metabolic syndrome and fall among the groups were analyzed.
Among 765 participants, the dynapenia group had higher metabolic profiles, body fat percentage, waist circumference, and fat to muscle ratio than the other groups, whereas the presarcopenia subjects had the lowest obesity parameters.
The fallers tended to have poorer muscle function than non-fallers.
Dr. Wei-Shiung Yang from The National Taiwan University Hospital said, “The impact of muscle mass or muscle strength on functional disability has attracted high levels of attention in the medical community.”
Muscle mass and muscle strength have been discussed together since presarcopenia and sarcopenia were defined in 2010 by the European Working Group on Sarcopenia in Older People.
Beyond the concepts of presarcopenia and sarcopenia, Clark and colleagues had innovatively described the concept of low muscle strength without low muscle mass as dynapenia.
In line with this definition, a meta-analysis from 42 longitudinal studies explored the idea that low muscle strength tended to play a more critical role in functional decline and poor health outcomes than low muscle mass among older adults.
In contrast, the other study found that both low muscle mass and low muscle strength played a synergistic effect in increasing the risk of losing physical independence.
They tried to further examine whether muscle function is a major determinant factor more than muscle mass on fall risk.
The Yang Research team concluded in their Aging-US Research Output, “Community-dwelling older people with dynapenia were more obese and had a higher risk of fall and metabolic syndrome than sarcopenia individuals. In contrast, presarcopenia older adults were less obese and had a lower risk of metabolic syndrome. Muscle function was more important than muscle mass on fall risk. Increased adiposity with or without reduced muscle mass was related to muscle function decline.”
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Correspondence to: Wei-Shiung Yang email: firstname.lastname@example.org
Keywords: dynapenia, obesity, fall, metabolic syndrome, fat to muscle ratio
Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways.
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