Electroconvulsive Therapy Pulse Amplitude and Clinical Outcomes

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Despite the proven antidepressant efficacy of electroconvulsive therapy (ECT) for depressive episodes (1), neurocognitive impairment remains a major concern of treatment, especially in areas of episodic memory and executive function (2). Demographic (age, premorbid intelligence, years of education), depression severity, and ECT treatment parameters (pulse-width, dose-titration, amplitude, electrode placement) influence ECT-mediated neurocognitive outcomes (3). The impact of variable pulse amplitudes on clinical and cognitive outcomes has yet to be investigated.

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