Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder

0
75

  • 1.

    Franke B, Michelini G, Asherson P, Banaschewski T, Bilbow A, Buitelaar JK, et al. Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan. Eur Neuropsychopharmacol. 2018;28:1059–88.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 2.

    Polanczyk GV, Salum GA, Sugaya LS, Caye A, Rohde LA. Annual research review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents. J Child Psychol Psychiatry. 2015;56:345–65.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 3.

    Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med. 2006;36:159–65.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 4.

    Bálint S, Czobor P, Komlósi S, Mészáros A, Simon V, Bitter I. Attention deficit hyperactivity disorder (ADHD): gender- and age-related differences in neurocognition. Psychol Med. 2009;39:1337–45.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 5.

    Ossmann JM, Mulligan NW. Inhibition and attention deficit hyperactivity disorder in adults. Am J Psychol. 2003;116:35–50.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 6.

    Boonstra AM, Oosterlaan J, Sergeant JA, Buitelaar JK. Executive functioning in adult ADHD: a meta-analytic review. Psychol Med. 2005;35:1097–108.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 7.

    Retz W, Stieglitz R-D, Corbisiero S, Retz-Junginger P, Rösler M. Emotional dysregulation in adult ADHD: what is the empirical evidence? Exp Rev Neurother. 2012;12:1241–51.

    CAS 
    Article 

    Google Scholar
     

  • 8.

    Ferrari AJ, Stockings E, Khoo J-P, Erskine HE, Degenhardt L, Vos T, et al. The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disord. 2016;18:440–50.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 9.

    Akiskal HS, Bourgeois ML, Angst J, Post R, Möller H, Hirschfeld R. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affect Disord. 2000;59(Suppl 1):S5–30.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 10.

    Brus MJ, Solanto MV, Goldberg JF. Adult ADHD vs. bipolar disorder in the DSM-5 era: a challenging differentiation for clinicians. J Psychiatr Pract. 2014;20:428–37.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 11.

    Marangoni C, De Chiara L, Faedda GL. Bipolar disorder and ADHD: comorbidity and diagnostic distinctions. Curr Psychiatry Rep. 2015;17:604.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 12.

    Wingo AP, Ghaemi SN. A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder. J Clin Psychiatry. 2007;68:1776–84.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 13.

    Torres I, Gómez N, Colom F, Jiménez E, Bosch R, Bonnín CM, et al. Bipolar disorder with comorbid attention-deficit and hyperactivity disorder. Main clinical features and clues for an accurate diagnosis. Acta Psychiatr Scand. 2015;132:389–99.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 14.

    Pinna M, Visioli C, Rago CM, Manchia M, Tondo L, Baldessarini RJ. Attention deficit-hyperactivity disorder in adult bipolar disorder patients. J Affect Disord. 2019;243:391–6.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 15.

    Larsson H, Rydén E, Boman M, Långström N, Lichtenstein P, Landén M. Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder. Br J Psychiatry. 2013;203:103–6.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 16.

    Faraone SV, Larsson H. Genetics of attention deficit hyperactivity disorder. Mol Psychiatry. 2018. https://doi.org/10.1038/s41380-018-0070-0. Accessed 11 Jun 2018.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • 17.

    Shih RA, Belmonte PL, Zandi PP. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int Rev Psychiatry. 2004;16:260–83.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 18.

    Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013;45:984–94.

    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • 19.

    Landaas ET, Johansson S, Halmøy A, Oedegaard KJ, Fasmer OB, Haavik J. Bipolar disorder risk alleles in adult ADHD patients. Genes Brain Behav. 2011;10:418–23.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 20.

    Schimmelmann BG, Hinney A, Scherag A, Pütter C, Pechlivanis S, Cichon S, et al. Bipolar disorder risk alleles in children with ADHD. J Neural Transm. 2013;120:1611–7.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 21.

    Neale BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch K-P, et al. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010;49:884–97.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 22.

    Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011;43:977–83.

    Article 
    CAS 

    Google Scholar
     

  • 23.

    van Hulzen KJE, Scholz CJ, Franke B, Ripke S, Klein M, McQuillin A, et al. Genetic overlap between attention-deficit/hyperactivity disorder and bipolar disorder: evidence from Genome-wide Association Study meta-analysis. Biol Psychiatry. 2017;82:634–41.

    PubMed 
    Article 

    Google Scholar
     

  • 24.

    Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet. 2019;51:63–75.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 25.

    Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51:793–803.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 26.

    Bulik-Sullivan BK, Finucane HK, Anttila V, Gusev A, Day FR, Loh P-R, et al. An atlas of genetic correlations across human diseases and traits. Nat Genet. 2015;47:1236–41.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 27.

    Smeland OB, Wang Y, Frei O, Li W, Hibar DP, Franke B, et al. Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophr Bull. 2018;44:854–64.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 28.

    Lee PH, Baker JT, Holmes AJ, Jahanshad N, Ge T, Jung J-Y, et al. Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia. Mol Psychiatry. 2016;21:1680–9.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 29.

    Smeland OB, Bahrami S, Frei O, Shadrin A, O’Connell K, Savage J, et al. Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Mol Psychiatry. 2019. https://doi.org/10.1038/s41380-018-0332-x. Accessed 4 Jan 2019.

  • 30.

    Schmitt J, Schwarz K, Baurecht H, Hotze M, Fölster-Holst R, Rodríguez E, et al. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J Allergy Clin Immunol. 2016;137:130–6.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 31.

    Baurecht H, Hotze M, Brand S, Büning C, Cormican P, Corvin A, et al. Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am J Hum Genet. 2015;96:104–20.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 32.

    Smeland OB, Frei O, Kauppi K, Hill WD, Li W, Wang Y, et al. Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA Psychiatry. 2017;74:1065–75.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 33.

    Bansal V, Mitjans M, Burik CAP, Linnér RK, Okbay A, Rietveld CA, et al. Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. Nat Commun. 2018;9:3078.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 34.

    Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genomic dissection of bipolar disorder and schizophrenia, including 28 Subphenotypes. Cell. 2018;173:1705–15.e16.

    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • 35.

    Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O’Donovan MC, et al. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013;92:197–209.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 36.

    Andreassen OA, Thompson WK, Dale AM. Boosting the power of schizophrenia genetics by leveraging new statistical tools. Schizophr Bull. 2013;40:13–7.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 37.

    Shadrin AA, Smeland OB, Zayats T, Schork AJ, Frei O, Bettella F, et al. Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment. J Am Acad Child Adolesc Psychiatry. 2018;57:86–95.

    PubMed 
    Article 

    Google Scholar
     

  • 38.

    Le Hellard S, Wang Y, Witoelar A, Zuber V, Bettella F, Hugdahl K, et al. Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment. Schizophr Bull. 2017;43:654–64.

    PubMed 

    Google Scholar
     

  • 39.

    Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, et al. Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease. Circulation. 2015;131:2061–9.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 40.

    Karch CM, Wen N, Fan CC, Yokoyama JS, Kouri N, Ross OA, et al. Selective genetic overlap between amyotrophic lateral sclerosis and diseases of the frontotemporal dementia spectrum. JAMA Neurol. 2018;75:860–75.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 41.

    Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, et al. Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurol. 2017;74:780–92.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 42.

    Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics Consortium. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015;47:291–5.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 43.

    Smeland OB, Frei O, Shadrin A, O’Connell K, Fan C-C, Bahrami S, et al. Discovery of shared genomic loci using the conditional false discovery rate approach. Hum Genet. 2019. https://doi.org/10.1007/s00439-019-02060-2. Accessed 13 Sep 2019.

  • 44.

    Watanabe K, Taskesen E, Bochoven Avan, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. Nature. Communications. 2017;8:1826.


    Google Scholar
     

  • 45.

    The 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature. 2015;526:68–74.

    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • 46.

    Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 2010;38:e164.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • 47.

    Kircher M, Witten DM, Jain P, O’Roak BJ, Cooper GM, Shendure J. A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet. 2014;46:310–5.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 48.

    Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 2012;22:1790–7.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 49.

    Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, et al. Integrative analysis of 111 reference human epigenomes. Nature. 2015;518:317–30.

    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • 50.

    Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48:481–7.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 51.

    MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, et al. The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Res. 2017;45:D896–901.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 52.

    GTEx Consortium. The genotype-tissue expression (GTEx) project. Nat Genet. 2013;45:580–5.

    Article 
    CAS 

    Google Scholar
     

  • 53.

    Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V, et al. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry. 2017;174:850–8.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 54.

    Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, et al. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013;73:667–78.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 55.

    Raj T, Chibnik LB, McCabe C, Wong A, Replogle JM, Yu L, et al. Genetic architecture of age-related cognitive decline in African Americans. Neurol Genet. 2017;3:e125.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 56.

    Fahira A, Li Z, Liu N, Shi Y. Prediction of causal genes and gene expression analysis of attention-deficit hyperactivity disorder in the different brain region, a comprehensive integrative analysis of ADHD. Behav Brain Res. 2019;364:183–92.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 57.

    Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol. 1998;16:111–35.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 58.

    Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, et al. NFKB1 and MANBA confer disease-susceptibility to primary biliary cholangitis via independent putative primary functional variants. Cell Mol Gastroenterol Hepatol. 2018. https://doi.org/10.1016/j.jcmgh.2018.11.006. Accessed 4 Dec 2018.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 59.

    Jones KA, Thomsen C. The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci. 2013;53:52–62.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 60.

    Claesdotter E, Cervin M, Åkerlund S, Råstam M, Lindvall M. The effects of ADHD on cognitive performance. Nord J Psychiatry. 2018;72:158–63.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 61.

    Strine TW, Lesesne CA, Okoro CA, McGuire LC, Chapman DP, Balluz LS, et al. Emotional and behavioral difficulties and impairments in everyday functioning among children with a history of attention-deficit/hyperactivity disorder. Prev Chronic Dis. 2006;3:A52.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 62.

    Czamara D, Tiesler CMT, Kohlböck G, Berdel D, Hoffmann B, Bauer C-P, et al. Children with ADHD symptoms have a higher risk for reading, spelling and math difficulties in the GINIplus and LISA plus cohort studies. PLoS One. 2013;8:e63859.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 63.

    Korrel H, Mueller KL, Silk T, Anderson V, Sciberras E. Research review: language problems in children with attention-deficit hyperactivity disorder—a systematic meta-analytic review. J Child Psychol Psychiatry. 2017;58:640–54.

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 64.

    Voigt RG, Katusic SK, Colligan RC, Killian JM, Weaver AL, Barbaresi WJ. Academic achievement in adults with a history of childhood attention-deficit/hyperactivity disorder: a population-based prospective study. J Dev Behav Pediatr. 2017;38:1–11.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 65.

    Solovieff N, Cotsapas C, Lee PH, Purcell SM, Smoller JW. Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet. 2013;14:483–95.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 66.

    Smoller JW, Andreassen OA, Edenberg HJ, Faraone SV, Glatt SJ, Kendler KS. Psychiatric genetics and the structure of psychopathology. Mol Psychiatry. 2019;24:409–20.

    PubMed 
    Article 

    Google Scholar
     

  • 67.

    Sullivan PF, Agrawal A, Bulik CM, Andreassen OA, Børglum AD, Breen G, et al. Psychiatric genomics: an update and an agenda. Am J Psychiatry. 2018;175:15–27.

    Article 

    Google Scholar
     

  • 68.

    Weber H, Kittel-Schneider S, Gessner A, Domschke K, Neuner M, Jacob CP, et al. Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. Neuropsychopharmacology. 2011;36:2076–85.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 69.

    Jiang Y, Zhang H. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. Genet Epidemiol. 2011;35:125–32.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 70.

    Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, et al. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci USA. 2009;106:7501–6.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 71.

    Pickard BS, Christoforou A, Thomson PA, Fawkes A, Evans KL, Morris SW, et al. Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder. Mol Psychiatry. 2009;14:874–84.

    CAS 
    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 72.

    Nurnberger JI, Koller DL, Jung J, Edenberg HJ, Foroud T, Guella I, et al. Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry. 2014;71:657–64.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Source link

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here