that contributes to poor treatment response, increased risk of relapse, and poorer
functional outcomes. This is especially true in late-life depression (LLD) where executive
dysfunction has long been considered an essential feature of the disorder.
In Morimoto et al, the authors describe a pilot study of a novel intervention addressing
cognitive dysfunction in LLD with neuroplasticity-based computerized cognitive remediation
remediation in patients with geriatric major depression: A randomized, double-blind,
Am J Geriatr Psychiatry.
The intervention significantly improved performance on cognitive control tasks compared
to the active control condition and transferred to other neuropsychological domains
beyond cognitive control. Furthermore, participants engaged in nCCR had significantly
higher response and remission rates, as well as improved functional outcomes compared
to the control group. These findings were particularly notable since the study participants
failed to respond to standard pharmacotherapy.
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